目的 研究羊耳菊(Inula cappa DC.)的化学成分。方法 采用溶剂提取，应用色谱技术分离纯化，根据化合物理化性质和光谱数据鉴定其结构。结果 分离并鉴定了17个化合物，分别为木栓酮(1)、表木栓醇(2)、α-香树脂醇(3)、β-香树脂醇(4)、benzyl 2-O-β-D-glucopyranosy-2，6-dihydroxybenzoate(5)、东莨菪素(6)、木犀草素-7-O-β-D-葡萄糖醛酸乙酯苷(7)、benzyl alcohol glucoside(8)、ophiopogonoside A(9)、芹菜素-7-O-β-D-葡萄糖苷(10)、木犀草素-7-O-β-D-芸香糖苷(11)、hydnocarpin-D(12)、木犀草素(13)、木犀草素-7-O-β-D-葡萄糖苷(14)、木犀草素-4′-O-β-D-葡萄糖苷(15)、槲皮素-3-O-β-D-葡萄糖苷(16)、juglans cerebroside A(17)。结论 化合物5、7~12、14、16~17为首次从该种植物中分离得到，化合物5、7、9、11、12、17为首次从该属植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Inula cappa. METHODS Chromatographic techniques were employed for isolation and purification of the constituents and their structures were determined by spectral analysis and chemical evidence. RESULTS Seventeen compounds were obtained and identified as friedelin(1), epifriedelanol(2), α-amyrin(3), β-amyrin(4), benzyl 2-O-β-D-glucopyranosy-2,6-dihydroxybenzoate(5), scopoletin(6), luteolin-7-O-β-D-glucuronide ethyl ester(7), benzyl alcohol glucoside(8), ophiopogonoside A(9), apigenin-7-O-β-D-glucoside(10), luteolin-7-O-β-D-rutinoside(11), hydnocarpin-D(12), luteolin(13), luteolin-7-O-β-D-glucoside(14), luteolin-4′-O-β-D-glucoside(15), quercetin-3-O-β-D-glucoside(16), and juglans cerebroside A(17). CONCLUSION Compounds 5, 7, 9, 11, 12, and 17 are for the first time obtained from the genus Inula and compounds 8, 10, 14, and 16 are isolated from Inula cappa for the first time.
关键词
羊耳菊 /
旋覆花属 /
化学成分 /
结构鉴定 /
benzyl 2-O-β-D-glucopyranosy-2 /
6-dihydroxybenzoate /
木犀草素-7-O-β-D-葡萄糖醛酸乙酯苷 /
ophiopogonoside A
{{custom_keyword}} /
Key words
Inula cappa /
Inula /
chemical constituents /
structure identification /
benzyl 2-O-β-D-glucopyranosy-2,6-dihydroxybenzoate /
luteolin-7-O-β-D-glucuronide ethyl ester /
ophiopogonoside A
{{custom_keyword}} /
中图分类号：
R284
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] ZHENG L H, HAO X J, YUAN C M, et al. Study on chemical constituents of Inula cappa . China J Chin Mater Med (中国中药杂志), 2015, 40(4):672-678.
[2] MO J J, XU M D, YANG D D, et al. Experimental study on anti-inflammatory and analgesic effects of ethanol of ethanol extracts of Dong-medicine Inula cappa . Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2012, 18(21):258-260.
[3] LIU S G, LI J, CHEN F C, et al. Studies on the antimicrobial activities of aqueous from Inula cappa DC in vitro . Lishizhen Med Mater Med Res(时珍国医国药), 2009, 20(12):3072-3074.
[4] HU L, HE Z S. Progress of constituents and pharmacological activities of Inula cappa . Chin J Mod Appl Pharm(中国现代应用药学), 2012, 29(10):889-894.
[5] GUAN H Y, LAN Y Y, LIAO S G, et al. Caffeoylquinic acid derivatives from Inula cappa . Nat Prod Res Dev(天然产物研究与开发), 2014, 26(12):1948-1952.
[6] LUO J G, KONG L Y. Lipophilic constituents from the leaves of Ipomoea batatas(cv. Simon). Nat Prod Res Dev(天然产物研究与开发), 2005, 17(2):166-168.
[7] CAI Y L, RUAN J L. Studies on the chemical constituents from the leaf of Liquidambar formosana Hance . J Chin Med Mater(中药材), 2005, 28(4):294-295.
[8] DAI Z, WANG G L, WANG F, et al. Chemical constituents of Balanophora simaoensis(Ⅰ). Chin Tradit Herb Drugs(中草药), 2005, 36(6):830-831.
[9] BRIGIDA D, MARINA D, ANTONIO F, et al. Potential allelochemicals from Sambucus nigra . Phytochemistry,2001, 58(7):1073-1081.
LIU Y M, LIANG G Y, ZHANG J X, et al. Studies on chemical constituents of Dichondra repens . Chin Pharm J(中国药学杂志), 2002, 37(8):577-579.
YANG N Y, DUAN J A, LI P, et al. Flavonoids from Glechoma longituba(Nakai)Kupr . J China Pharm Univ(中国药科大学学报), 2005, 36(3):210-212.
SEIGLER D S, PAULI G F, NAHRSTEDT A, et al. Cyanogenic allosides and glucosides from Passiflora edulis and Carica papaya . Phytochemistry,2002, 60(8):873-882.
CHENG Z H, WU T, BLIGH S W, et al. Cis-eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopoqon japonicus . J Nat Prod,2004, 67(10):1761-1763.
WU X, LIU J, YU Z B, et al. Studies on flavones in of Lavandula augustifolia . China J Chin Mater Med (中国中药杂志), 2007, 32(9):821-823.
WANG M, SIMON J E, HE K, et al. Analysis of antioxidative phenolic compounds in artichoke(Cynara scolymus L.). J Agric Food Chem,2003, 51(3):601-608.
GUZ N R, STERMITZ F R. Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans . J Nat Prod, 2000, 63(8):1140-1145.
CHEN G M, ZHANG J Y, ZHANG X P, et al. Studies on chemical constituents of flavonoid from Verbena officinals . J Chin Med Mater(中药材), 2006, 29(7):677-678.
SHI L, JI Z Q, KANG W Y. Study on chemical constituents in compound Lobelia chinensis . J China Pharm(中国药房), 2014, 25(35):3308-3310.
ZHANG J, KONG L Y. Study on chemical constituents from Artemisia selengensis leaves . Chin Pharm J(中国药学杂志), 2005, 40(3):1178-1180.
GUO Q L, YANG J S, LIU J X. Studies on chemical constituents in fruits of Rubus chingii . Chin Pharm J(中国药学杂志), 2007, 42(15):1141-1143.
LING T J, XIA T, WAN X C, et al. Cerebrosides from the roots of Serratula chinensis . Molecules, 2006, 11(9):677-683.
SUN J M, CHANG R L, ZHANG H. A new cerebrogalactoside from Juglans mandshurica . Chem Nat Compd, 2011, 47(2):254-256.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金资助项目(81360780);贵州省优青项目(黔科合人字(2015)11号);贵州省科技厅平台项目(黔科合重G字 4001);贵州省省教育厅平台项目(黔教合协同创新字04;黔教社发419号)
{{custom_fund}}
PDF(1036 KB)
